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Mouth Sores Are a Harmful Side Effect of Many Chemotherapies

Learn about the benefits of cooling the mouth during chemotherapy, a clinically proven approach to protect against chemotherapy-induced mouth sores (oral mucositis).

The Chemo Mouthpiece® is an FDA-cleared oral cryotherapy device designed to reduce the incidence and severity of chemotherapy induced oral mucositis in adult patients.

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Starting chemotherapy?

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How Oral Mucositis May Affect You During Chemo

Development and progression of oral mucositis (mouth sores) may cause clinically significant problems, including:

  • ✴ Opioid and/or analgesic use for pain
  • ✴ Dose-limits/treatment interruptions
  • ✴ Weight loss, inability to eat/drink
  • ✴ Pathway for infection
  • ✴ Increased ER visits and admittance
  • ✴ Significantly higher healthcare costs
  • ✴ Difficulty eating, talking, sleeping, smiling
Oral mucositis
Oral mucositis

Examples of oral mucositis.

If chemotherapy is part of your treatment plan, talk with your healthcare provider before starting chemotherapy about your risk for oral mucositis and if the Chemo Mouthpiece as oral cryotherapy may be part of your supportive care.

Learn how oral cryotherapy works →

Chemo Mouthpiece Therapy Kit

About the Chemo Mouthpiece®

The Chemo Mouthpiece® is an FDA-cleared oral cooling device used during chemo infusion and at home afterwards.

Developed by a cancer survivor (see David’s story) who experienced firsthand the severe effects of oral mucositis, the device is easy to use and delivers consistent cooling to help reduce the risk of painful mouth sores.

Patients using the Chemo Mouthpiece experienced significantly less pain and used significantly less analgesics and opioids.

The Chemo Mouthpiece requires a prescription from a healthcare provider. The device is shipped directly to patients from a specialty pharmacy.

Questions about access or cost?

Submit the form and a member of our U.S.-based team will follow up promptly.

Chemo Mouthpiece Therapy Kit
Woman sitting with Chemo Mouthpiece device

Designed with Cancer Patients in Mind

Portable & reusable. Easy to use & clean

Each Chemo Mouthpiece device contains prefilled internal chambers that are frozen before use.

When placed in the mouth, the device is designed to deliver consistent cooling in the oral cavity. Each kit includes:

  • ❄ Six prefilled oral cooling devices
  • ❄ Cooler, insulted sleeves & cold packs
  • ❄ Cleaning tools
  • ❄ Simple instructions for use

Patients typically use a frozen device immediately before, during, and after their chemotherapy infusion, based on guidance from their care team.

Questions about access or cost?

Thermal images comparing before and after device use.

The Chemo Mouthpiece cools the entire oral cavity evenly. Darker areas represent colder temperatures. (Data on file)

How Oral Cryotherapy Works During Chemotherapy

Three Chemo Mouthpiece devices.The Chemo Mouthpiece® is an oral cryotherapy (cold temperature) device designed to deliver consistent, uniform cooling across the oral cavity.

When a cold Chemo Mouthpiece is placed in the mouth, the cooling effect causes vasoconstriction of local blood vessels which physically decreases the flow of circulating chemotherapy in the oral cavity.

This reduces the damage chemo drugs can cause to the mucous membranes in the mouth, reducing the incidence and severity of oral mucositis.

Seated woman in a clinical trial

The Chemo Mouthpiece was Studied in a Clinical Trial

Born from personal experience and backed by clinical evidence, the Chemo Mouthpiece was evaluated in a multi-center, randomized clinical trial.

The Chemo Mouthpiece® is clinically proven to reduce the incidence and severity of chemotherapy induced oral mucositis.

See the Clinical Study →

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Financial Support for Patients

We understand cancer diagnosis and its treatment can feel overwhelming.

Our Patient Assistance Program (PAP) is available to help eligible patients access the Chemo Mouthpiece and have one less thing to worry about.

Available in the U.S. by prescription only.

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Our U.S.-based team is available to help and responds promptly.

Doctor holding patient's hand

For Healthcare Professionals

Nurse holding Chemo Mouthpiece device.

Information for clinicians on accessing and prescribing the Chemo Mouthpiece® for adult patients receiving chemotherapy.

Questions about access or how to prescribe?

Contact Our Team   How to Prescribe

INDICATION (Rx Only):

The Chemo Mouthpiece® is intended to be used to cool the oral mucosa to reduce the incidence and severity of chemotherapy induced oral mucositis in adult patients.
View Full Instructions for Use and Prescriber Information.